Mortality
Males with pathogenic MECP2 mutations usually die during infancy stage from severe encephalopathy, unless they have an extra X chromosome (often described as Klinefelter's syndrome), or have somatic mosaicism.
Females can live up to 40 years or more. Abnormal lab data values on Rett disorder may show:
* EEG abnormalities from 2 years of age
* atypical glycolipids
* elevated levels of beta-endorphins and glutamate
* reduction of substance P
* decreased levels of nerve growth factors
Mortality rate among children with Rett disorder is approximately at 1.2% per year.
High proportion of deaths are abrupt; due to:
* heart conduction problem - abnormally prolonged QT interval on ECG
* spontaneous brainstem dysfunction
* respiratory arres
Disorders & Disabilities
- ADHD
- Agoraphobia
- Angelman Syndrome
- Asperger Syndrome
- Autism
- Bipolar Disorder
- Blindness
- Cerebral Palsy
- Childhood Disintegrative Disorder
- Cluttering
- Conduct Disorder
- Deafblindness
- Deafness
- Depression
- Development Delay
- Developmental Language Learning Impairments
- Down Syndrome
- Dyscalculia
- Dysgraphia
- Dyslexia
- Dysphasia
- Dyspraxia
- Expressive Language Disorder
- Fragile X Syndrome
- Hyperlexia
- Language Delay
- Lisp
- Mitochondrial Disease
- Obsessive-Compulsive Disorder (OCD)
- Oppositional defiant disorder
- P.A.N.D.A.S.
- Rett Syndrome
- Selective Mutism
- Sensory Integration Dysfunction
- Serious Emotional Disturbance
- Social Anxiety
- Stereotypic Movement Disorder
- Stuttering
- Tourette Syndrome (TS)
- Usher Syndrome
- Williams Syndrome