Prader–Willi syndrome appeared in the UK media in July 2007 when Channel 4 aired a program Can't Stop Eating, surrounding the everyday lives of two Prader-Willi patients, Joe and Tamara.
An individual with Prader-Willi Syndrome featured in the episode entitled "Dog Eat Dog" of the television series CSI: Crime Scene Investigation (aired on November 24, 2005).
Another individual with Prader–Willi syndrome, Ethan Starkweather, was on Extreme Makeover: Home Edition originally aired on Mothers Day 2010.
Actress and neuroscientist Mayim Bialik wrote a thesis on Prader–Willi syndrome for her Ph.D, which was completed in 2008.
On TLC's My Deadly Appetite (aired in December 2010), a patient named Will was treated for the condition (as well as others featured).