The diagnosis of Angelman syndrome is based on:
Aa history of delayed motor milestones and then later a delay in general development, especially of speech
Unusual movements including fine tremors, jerky limb movements, hand flapping and a wide-based, stiff-legged gait.
Characteristic facial appearance.
A history of epilepsy and an abnormal EEG tracing.
A happy disposition with frequent laughter
A deletion on chromosome 15
Likes water, paper, plastic and noise making object